Propionate pathway metabolites as regulators of fatty and dicarboxylic acid oxidation in liver mitochondria
Fedotcheva, NI; Gessler, NN; Anikeeva, SP; Ignat'ev, DA; Bykhovskiĭ, VYa; Kondrashova, MN
HERO ID
4935815
Reference Type
Journal Article
Year
1993
Language
English
| HERO ID | 4935815 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Propionate pathway metabolites as regulators of fatty and dicarboxylic acid oxidation in liver mitochondria |
| Authors | Fedotcheva, NI; Gessler, NN; Anikeeva, SP; Ignat'ev, DA; Bykhovskiĭ, VYa; Kondrashova, MN |
| Journal | Biochemistry (Moscow) |
| Volume | 58 |
| Issue | 4 |
| Page Numbers | 387-391 |
| Abstract | The functioning of the propionate pathway of oxidation substrate metabolism was studied in the norm and under vitamin B-12 deficiency. The pathway was shown to play an important role in the proper oxidative process since its inhibition in B-12-deficient animals results in a decrease in respiration, palmitoylcarnitine and succinate oxidation rates, and coupling of oxidative phosphorylation. Succinate, the end product of the propionate pathway, normalizes respiration and restores the rate of palmitoylcarnitine oxidation in B-12-deficient animals, showing its crucial role in the propionate pathway. In vivo propionate inhibits, whereas methyl malonate stimulates, palmitoylcarnitine respiration, but only in control animals. In B-12-deficient animals the sensitivity to these metabolites is decreased. |
| Wosid | WOS:A1993MF73800011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Translated from Biokhimiya, Vol. 58, No. 4, pp. 599-605, April, 1993. |
| Is Public | Yes |
| Language Text | English |
| Keyword | propionate; methyl malonate; succinate; oxidizing activity; liver mitochondria |
| Relationship(s) |
|