Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats
Gołembiowska, K; Dziubina, A
HERO ID
4933488
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 4933488 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats |
| Authors | Gołembiowska, K; Dziubina, A |
| Journal | Neuropharmacology |
| Volume | 47 |
| Issue | 3 |
| Page Numbers | 414-426 |
| Abstract | The influence of the selective adenosine A(2A) receptor antagonist ZM 241385 on exogenous l-DOPA-derived dopamine (DA) release in intact and dopamine-denervated rats was studied using an in vivo microdialysis in freely moving animals. Local infusion of l-DOPA (2.5 microM) produced a marked increase in striatal extracellular DA level in intact and malonate-lesioned rats. Intrastriatal perfusion of ZM 241385 (50-100 microM) had no effect on basal extracellular DA level, but enhanced dose-dependently the l-DOPA-induced DA release in intact and malonate-lesioned animals. A non-selective adenosine A(2A) receptor antagonist DMPX (100 microM), similarly to ZM 241385, accelerated conversion of l-DOPA in intact and malonate-denervated rats. This effect was not produced by the adenosine A(1) receptor antagonist, CPX (10-50 microM). However, ZM 241385 did not affect the l-DOPA-induced DA release in rats pretreated with reserpine (5 mg/kg i.p.) and alpha-methyl-p-tyrosine (AMPT, 300 mg/kg i.p.). Obtained results indicate that blockade of striatal adenosine A(2A) receptors increases the l-DOPA-derived DA release possibly by indirect mechanism exerted on DA terminals, an effect dependent on striatal tyrosine hydroxylase activity. Selective antagonists of adenosine A(2A) receptors may exert a beneficial effect at early stages of Parkinson's disease by enhancing the therapeutic efficacy of l-DOPA applied exogenously. |
| Doi | 10.1016/j.neuropharm.2004.04.018 |
| Pmid | 15275831 |
| Wosid | WOS:000223235600012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242690678&doi=10.1016%2fj.neuropharm.2004.04.018&partnerID=40&md5=ea7fdb0504a5a4f7ccbb7a26a653aaad |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus |