Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP
Andreassen, OA; Ferrante, RJ; Dedeoglu, A; Albers, DW; Klivenyi, P; Carlson, EJ; Epstein, CJ; Beal, MF
HERO ID
4933486
Reference Type
Journal Article
Year
2001
Language
English
PMID
| HERO ID | 4933486 |
|---|---|
| In Press | No |
| Year | 2001 |
| Title | Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP |
| Authors | Andreassen, OA; Ferrante, RJ; Dedeoglu, A; Albers, DW; Klivenyi, P; Carlson, EJ; Epstein, CJ; Beal, MF |
| Journal | Experimental Neurology |
| Volume | 167 |
| Issue | 1 |
| Page Numbers | 189-195 |
| Abstract | There is substantial evidence implicating mitochondrial dysfunction and free radical generation as major mechanisms of neuronal death in neurodegenerative diseases. The major free radical scavenging enzyme in mitochondria is manganese superoxide dismutase (SOD2). In the present study we investigated the susceptibility of mice with a partial deficiency of SOD2 to the neurotoxins 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP), 3-nitropropionic acid (3-NP), and malonate, which are commonly used animal models of Parkinson's and Huntington's disease. Heterozygous SOD2 knockout (SOD2(+/-)) mice showed no evidence of neuropathological or behavioral abnormalities at 2-4 months of age. Compared to littermate wild-type mice, mice with partial SOD2 deficiency showed increased vulnerability to dopamine depletion after systemic MPTP treatment and significantly larger striatal lesions produced by both 3-NP and malonate. SOD2(+/-) mice also showed an increased production of "hydroxyl" radicals after malonate injection measured with the salicylate hydroxyl radical trapping method. These results provide further evidence that reactive oxygen species play an important role in the neurotoxicity of MPTP, malonate, and 3-NP. These findings show that a subclinical deficiency in a free radical scavenging enzyme may act in concert with environmental toxins to produce selective neurodegeneration. |
| Doi | 10.1006/exnr.2000.7525 |
| Pmid | 11161607 |
| Wosid | WOS:000166432900020 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus |