[The effect of metabolites of the propionate pathway on the oxidative activity of liver mitochondria]
Fedotcheva, NI; Gessler, NN; Bykhovskiĭ, VIa; Kondrashova, MN
HERO ID
4923735
Reference Type
Journal Article
Year
1991
Language
Russian
PMID
| HERO ID | 4923735 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | [The effect of metabolites of the propionate pathway on the oxidative activity of liver mitochondria] |
| Authors | Fedotcheva, NI; Gessler, NN; Bykhovskiĭ, VIa; Kondrashova, MN |
| Journal | Biokhimiya |
| Volume | 56 |
| Issue | 3 |
| Page Numbers | 426-433 |
| Abstract | Methylmalonate and propionate, the major metabolites of the propionate pathway of fatty and amino acid metabolism used at 1-4 mM cause selective inhibition of succinate and palmitoyl carnitine oxidation in liver mitochondria. Methylmalonate is more specific towards succinate, whereas propionate--towards palmitoyl carnitine oxidation. Methylmalonate is transported to mitochondria at a high rate with no effect on succinate transport. Being injected intramusculary methylmalonate has no inhibiting effect on the oxidative activity of mitochondria but is able to activate succinate and palmitoyl carnitine oxidation. The inhibiting effect of propionate on palmitoyl carnitine oxidation is a long-term one. Injections of these metabolites precursors, isoleucine, methionine and valine, produce an activating effect on succinate oxidation. Thus, propionate pathway metabolites may participate in the regulation of lipid-carbohydrate metabolism. |
| Pmid | 1883904 |
| Wosid | BCI:BCI199192038804 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Russian |