RIFM fragrance ingredient safety assessment, diethyl malonate, CAS Registry Number 105-53-3
Api, AM; Belsito, D; Botelho, D; Bruze, M; Burton, GA; Buschmann, J; Dagli, ML; Date, M; Dekant, W; Deodhar, C; Francis, M; Fryer, AD; Jones, L; Joshi, K; La Cava, S; Lapczynski, A; Liebler, DC; O'Brien, D; Patel, A; Penning, TM; Ritacco, G; Romine, J; Sadekar, N; Salvito, D; Schultz, TW; Sipes, IG; Sullivan, G; Thakkar, Y; Tokura, Y; Tsang, S
HERO ID
4923458
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 4923458 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | RIFM fragrance ingredient safety assessment, diethyl malonate, CAS Registry Number 105-53-3 |
| Authors | Api, AM; Belsito, D; Botelho, D; Bruze, M; Burton, GA; Buschmann, J; Dagli, ML; Date, M; Dekant, W; Deodhar, C; Francis, M; Fryer, AD; Jones, L; Joshi, K; La Cava, S; Lapczynski, A; Liebler, DC; O'Brien, D; Patel, A; Penning, TM; Ritacco, G; Romine, J; Sadekar, N; Salvito, D; Schultz, TW; Sipes, IG; Sullivan, G; Thakkar, Y; Tokura, Y; Tsang, S |
| Journal | Food and Chemical Toxicology |
| Abstract | Summary: The use of this material under current conditions is supported by existing information. The material diethyl malonate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Target data show that diethyl malonate is not genotoxic. The repeated dose and reproductive toxicity endpoints were completed using dimethyl malonate (CAS# 108-59-8) as a read-across analog, which provided an MOE > 100. Data from target material and read-across analog, pentanedioic acid, 1,5-dimethyl ester (CAS# 1119-40-0) show that is material is not a concern for skin sensitization. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated; diethyl malonate was found not to be a PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are < 1. |
| Doi | 10.1016/j.fct.2018.08.059 |
| Pmid | 30149112 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |