Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin
Weiping, S; Changqing, Y; Yanjing, C; Zhiguo, Z; Xiangzheng, K
| HERO ID | 1613340 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin |
| Authors | Weiping, S; Changqing, Y; Yanjing, C; Zhiguo, Z; Xiangzheng, K |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 48 |
| Issue | 1 |
| Page Numbers | 13-16 |
| Abstract | A kind of amphiphilic derivatives of chitosan (2-hydroxyl-3-butoxyl)-propylcarboxymethyl-chitosan (HBP-CMCHS), has been synthesized, and the critical micelle concentration (cmc) of HBP-CMCHS was detected by the fluorescence method. The puerarin-loaded HBP-CMCHS micellar system was prepared by physical entrapped method. Result showed that when adding the same amount of puerarin, the solubilizing capacity was enhanced by increasing the concentration of HBP-CMCHS and temperature. Puerarin-loaded micellar system of HBP-CMCHS was characterized by TEM and DLS. TEM photograph revealed that the micelles were spherical and puerarin was solubilized in the cores of the spherical polymeric micelles. DLS showed that after solubilization the size of the micelles became bigger. In vitro tests showed that puerarin was slowly released from micellar solution and the release lasted up to 60 h by means of the dialysis method. |
| Doi | 10.1016/j.colsurfb.2006.01.005 |
| Pmid | 16466908 |
| Wosid | WOS:000236167800003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus; 2006) |
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