Factors that affect the covalent binding and toxicity of drugs
Gillette, JR
HERO ID
9905
Reference Type
Book/Book Chapter
Year
1973
Language
English
| HERO ID | 9905 |
|---|---|
| Year | 1973 |
| Title | Factors that affect the covalent binding and toxicity of drugs |
| Book Title | Pharmacology and the future of man: Proceedings of the Fifth International Congress on Pharmacology: Vol. 2: Toxicological Problems |
| Authors | Gillette, JR |
| Editor | Acheson, GH; Loomis, TA |
| Publisher Text | S. Karger AG |
| City | Basel, Switzerland |
| Page Numbers | 187-202 |
| Abstract | Chemically inert substances can be transformed in the body to active intermediates that mediate a variety of toxicities including cellular necrosis, methemoglobinemia, porphyria, tumor formation and mutagenic effects. In addition, many hypersensitive reactions and fetotoxic reactions and probably mediated by active intermediates. In some instances the active intermediate apparently acts by combining reversibly with vitally important intracellular components but in others the intermediate acts by combining covalently with tissue macromolecules. This paper is concerned with some of the factors that affect covalent binding and toxicity of drugs. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | San Francisco, CA |
| Isbn | 9783805514712 |
| Conference Name | Fifth International Congress on Pharmacology |
| Conference Date | July 23-28, 1972 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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