Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk
Gladen, BC; Rogan, WJ; Hardy, P; Thullen, J; Tingelstad, J; Tully, M
HERO ID
95108
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 95108 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk |
| Authors | Gladen, BC; Rogan, WJ; Hardy, P; Thullen, J; Tingelstad, J; Tully, M |
| Journal | Journal of Pediatrics |
| Volume | 113 |
| Issue | 6 |
| Page Numbers | 991-995 |
| Abstract | Objective: To determine whether exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE), either transplacentally or through breast feeding, affected scores on the Bayley Scales of Infant Development at 6 or 12 months of age. Design: Cohort followed from birth to 1 year of age. Setting: General community. Participants: Volunteer sample of 858 infants, of whom 802 had Bayley scores available at either 6 months or 12 months or both. Interventions: None. Measurements and main results: Bayley scales and chemical measurements were done independently. Higher transplacental exposure to PCBs was associated with lower psychomotor scores at both 6 and 12 months of age; the difference between the mean scores in the lowest and highest PCB groups was 7 points at 6 months and 8 points at 12 months. Higher transplacental exposure to DDE was associated with higher mental scores at 6 months of age (the difference between the mean scores in the lowest and highest DDE groups was 6 points), but no relationship was seen at 12 months. Exposure to either chemical through breast feeding was apparently unrelated to Bayley scores. Conclusions: Transplacental exposure to PCBs was associated with lower psychomotor scores. No deleterious effects were associated with breast feeding. |
| Doi | 10.1016/S0022-3476(88)80569-9 |
| Pmid | 3142988 |
| Wosid | WOS:A1988R309300007 |
| Url | https://search.proquest.com/docview/50015794?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: J PEDIATR 113 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | article; Breast Feeding; Child Development; Child, Preschool; Dichlorodiphenyl Dichloroethylene; Follow-Up Studies; Infant, Newborn; Intelligence; Milk, Human; Neuropsychological Tests; Polychlorinated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; breast milk; food contamination; metabolites; placenta; infant development; DDT (pesticide); DDE (pesticide) |
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