Some hepatotoxic actions of hexachloroethane and its metabolites in sheep
Fowler, JSL
HERO ID
94838
Reference Type
Journal Article
Year
1969
Language
English
PMID
| HERO ID | 94838 |
|---|---|
| In Press | No |
| Year | 1969 |
| Title | Some hepatotoxic actions of hexachloroethane and its metabolites in sheep |
| Authors | Fowler, JSL |
| Journal | British Journal of Pharmacology |
| Volume | 35 |
| Issue | 3 |
| Page Numbers | 530-542 |
| Abstract | 1. Pentachloroethane and tetrachloroethylene were major metabolites of hexachloroethane in sheep.2. Concentrations of hexachloroethane, pentachloroethane and tetrachloroethylene were determined by gas-liquid chromatography in blood, bile, faeces, urine and tissues after oral administration of hexachloroethane emulsions to sheep.3. Increased blood concentrations of sorbitol dehydrogenase, glutamate dehydrogenase, and ornithine carbamoyl transferase were found to follow oral administration of hexachloroethane or pentachloroethane.4. The rate of bromsulphthalein transfer from liver cells to bile was found to decrease after oral administration of hexachloroethane. |
| Pmid | 5809742 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |