Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide
Kosaka, H; Uozumi, M; Nakajima, T
HERO ID
90850
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 90850 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Induction of SOS functions in Escherichia coli and biosynthesis of nitrosamine in rabbits by nitrogen dioxide |
| Authors | Kosaka, H; Uozumi, M; Nakajima, T |
| Journal | Environmental Health Perspectives |
| Volume | 73 |
| Page Numbers | 153-156 |
| Abstract | Nitrogen dioxide induced SOS functions in Salmonella typhimurium and Escherichia coli K-12 and was mutagenic in Escherichia coli WP2. When a rabbit was administered aminopyrine intravenously and administered nitrogen dioxide by inhalation, N-nitrosodimethylamine was detected in its blood. Analysis was conducted with 15N-nitrosodimethylamine as an internal standard by a combination of capillary gas chromatography and mass spectrometry. Accompanying administration of cystamine increased the blood concentration of N-nitrosodimethylamine in the rabbit, suggesting inhibition of its metabolism. Concurrent sulfur trioxide inhalation increased N-nitrosodimethylamine formation in the rabbit. |
| Pmid | 3311723 |
| Wosid | WOS:A1987K022400015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |