Effect of methanol on endogenous and exogenous carnitine levels in rat plasma
Olszowy, Z; Czech, E; Nowicka, J
HERO ID
90793
Reference Type
Journal Article
Year
2005
Language
English
PMID
| HERO ID | 90793 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Effect of methanol on endogenous and exogenous carnitine levels in rat plasma |
| Authors | Olszowy, Z; Czech, E; Nowicka, J |
| Journal | Archives of Toxicology |
| Volume | 79 |
| Issue | 10 |
| Page Numbers | 571-581 |
| Abstract | #The effect of methanol on the levels of endogenous carnitine and its derivatives was studied in male Sprague-Dawley rats aged three months. In addition, the effect of L-carnitine supplementation on metabolic disturbances caused by methanol intoxication was studied. The rats were randomized into six groups, including two control groups. Methanol was given at 1/4 LD50 and 1/2 LD50/kg b.w. (or water in control) through an intragastric tube, and L-carnitine (or 0.9% NaCl in the control) was injected intraperitoneally. The levels of plasma L-carnitine and its derivatives were measured at selected time points for four days. Following methanol administration, the rats exhibited dose-dependent increases in L-carnitine levels and altered ratios of L-carnitine and its derivatives. L-carnitine supplementation accelerated the normalization of metabolic disturbances, as indicated by the acylcarnitine to free carnitine ratio (AC/FC). The protective effect of L-carnitine is supported by the fact that 100% of the methanol-treated rats supplemented with carnitine survived, while 8/60 rats and 27/101 rats died at methanol doses of 1/4 LD50 and 1/2 LD50, respectively, in groups without L-carnitine supplementation. |
| Doi | 10.1007/s00204-004-0646-0 |
| Pmid | 15889238 |
| Wosid | WOS:000232663600004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Arch. Toxicol. 79: 571-581. |
| Is Public | Yes |
| Language Text | English |
| Keyword | L-carnitine; methanol; rats |
| Is Qa | No |