Associations of traffic-related air pollutants with hospitalisation for first acute myocardial infarction: The HEAPSS study
Lanki, T; Pekkanen, J; Aalto, P; Elosua, R; Berglind, N; D'Ippoliti, D; Kulmala, M; Nyberg, F; Peters, A; Picciotto, S; Salomaa, V; Sunyer, J; Tiittanen, P; Von Klot, S; Forastiere, F
HERO ID
89788
Reference Type
Journal Article
Year
2006
Language
English
PMID
| HERO ID | 89788 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Associations of traffic-related air pollutants with hospitalisation for first acute myocardial infarction: The HEAPSS study |
| Authors | Lanki, T; Pekkanen, J; Aalto, P; Elosua, R; Berglind, N; D'Ippoliti, D; Kulmala, M; Nyberg, F; Peters, A; Picciotto, S; Salomaa, V; Sunyer, J; Tiittanen, P; Von Klot, S; Forastiere, F |
| Journal | Occupational and Environmental Medicine |
| Volume | 63 |
| Issue | 12 |
| Page Numbers | 844-851 |
| Abstract | Background: Acute myocardial infarction (AMI) is the leading cause of death attributed to cardiovascular diseases. An association between traffic-related air pollution and AMI has been suggested, but the evidence is still limited. Objectives: to evaluate in a multi-centre study association between hospitalisation for first AMI and daily levels of traffic-related air pollution. Methods: We collected data on first AMI hospitalisations in 5 European cities. AMI registers were available in Augsburg and Barcelona; hospital discharge registers (HDRs) were used in Helsinki, Rome and Stockholm. NO2, CO and PM10 (particles <10 mu m) were measured at central monitoring sites. Particle number concentration (PNC), a proxy for ultrafine particles (<0.1 mu m), was measured for a year in each centre, and then modelled retrospectively for the whole study period. We used generalized additive models for statistical analyses. Age and 28-day fatality and season were considered as potential effect modifiers in the 3 HDR centres. Results: Nearly 27 000 cases of first AMI were recorded. There was a suggestion of an association of the same day CO and PNC levels with AMI: RR=1.005 (95% confidence interval: 1.000-1.010) per 0.2 mg/m3 and RR=1.005 (95%CI: 0.996-1.015) per 10000 particles/cm3, respectively. However, associations were only observed in the 3 cities with HDR, where power for city-specific analyses was higher. We observed in these cities the most consistent associations among fatal cases aged <75 years: RR at 1-day lag for CO=1.021 (95%CI: 1.000-1.048) per 0.2 mg/m3, for PNC= 1.058 (95% CI: 1.012-1.107) per 10000 particles/cm3, and for NO2=1.032 (95%CI: 0.998-1.066) per 8 mu g/m3. Effects of air pollution were more pronounced during the warm than the cold season. Conclusions: We found support for the hypothesis that exposure to traffic-related air pollution increases the risk of AMI. Most consistent associations were observed among fatal cases aged <75 years and in the warm season. |
| Doi | 10.1136/oem.2005.023911 |
| Pmid | 16912091 |
| Wosid | WOS:000242421300010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Occup. Environ. Med. 63: 844-851. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |