Phthalates: Toxicogenomics and inferred human diseases
Singh, S; Li, SS
HERO ID
787940
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 787940 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Phthalates: Toxicogenomics and inferred human diseases |
| Authors | Singh, S; Li, SS |
| Journal | Genomics |
| Volume | 97 |
| Issue | 3 |
| Page Numbers | 148-157 |
| Abstract | Phthalates are widely used as plasticizers to soften and increase the flexibility in polyvinyl chloride plastics, but they can leach into the surrounding environment. There is sufficient evidence in rodents that phthalate exposure causes developmental and reproductive toxicity. The curated interactions between 16 phthalates and genes/proteins were obtained from Comparative Toxicogenomics Database (CTD), and a total of 445 interactions between the five most frequently curated phthalates (DEHP/MEHP and DBP/BBP/MBP) and 249 unique genes/proteins were found. The GeneOntology, pathways and networks of these 249 unique genes/proteins were fully analyzed. The pathways and networks of top 34 genes/proteins were found to be very similar to those of the 249 unique genes/proteins. Thus, the top 34 genes/proteins may serve as molecular biomarkers of phthalate toxicity. The top three phthalate toxicity categories were found to be cardiotoxicity, hepatotoxicity and nephrotoxicity, and the top 20 diseases included cardiovascular, liver, urologic, endocrine and genital diseases. |
| Doi | 10.1016/j.ygeno.2010.11.008 |
| Pmid | 21156202 |
| Wosid | WOS:000288147500002 |
| Url | http://www.sciencedirect.com/science/article/pii/S0888754310002454 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000288147500002 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Databases, Genetic; Diethylhexyl Phthalate/ analogs & derivatives/ toxicity; Disease/ etiology/genetics; Environmental Exposure/adverse effects; Genetic Markers; Humans; Metagenomics; Phthalic Acids/ toxicity; Plasticizers/ toxicity |
| Is Peer Review | Yes |
| Relationship(s) |
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