Residential traffic-related pollution exposures and exhaled nitric oxide in the children's health study
Eckel, SP; Berhane, K; Salam, MT; Rappaport, EB; Linn, WS; Bastain, TM; Zhang, Y; Lurmann, F; Avol, EL; Gilliland, FD
HERO ID
786578
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 786578 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Residential traffic-related pollution exposures and exhaled nitric oxide in the children's health study |
| Authors | Eckel, SP; Berhane, K; Salam, MT; Rappaport, EB; Linn, WS; Bastain, TM; Zhang, Y; Lurmann, F; Avol, EL; Gilliland, FD |
| Journal | Environmental Health Perspectives |
| Volume | 119 |
| Issue | 10 |
| Page Numbers | 1472-1477 |
| Abstract | BACKGROUND: The fractional concentration of nitric oxide in exhaled air (FeNO) potentially detects airway inflammation related to air pollution exposure. Existing studies have not yet provided conclusive evidence on FeNO's association with traffic-related pollution (TRP). OBJECTIVES: To evaluate the association of FeNO with residential TRP exposure in a large cohort of children. METHODS: We related FeNO measured on 2,143 children (ages 7-11) who participated in the Southern California Children's Health Study (CHS) to five classes of metrics of residential TRP: distances to freeways and major roads; length of all and local roads within circular buffers around the home; traffic densities within buffers; annual average line source dispersion modeled NOx from freeways and non-freeway roads; and predicted annual average NO, NO2, and NOx from a model based on intra-community sampling in the CHS. RESULTS: In children with asthma, length of roads was positively associated with FeNO, with stronger associations in smaller buffers (46.7% (95% confidence interval (CI): 14.3, 88.4), 12.4% (95% CI: -8.8, 38.4), and 4.1% (95% CI: -14.6, 26.8) higher FeNO for 100-, 300-, and 1000-m increases in the length of all roads in 50-, 100-, and 200-m buffers, respectively). Other TRP metrics were not significantly associated with FeNO, even though the study design was powered to detect exposures explaining as little as 0.4% of the variation in natural log transformed FeNO (R2 = 0.004). CONCLUSION: Length of road was the only indicator of residential TRP exposure associated with airway inflammation in children with asthma, as measured by FeNO. |
| Doi | 10.1289/ehp.1103516 |
| Pmid | 21708511 |
| Wosid | WOS:000295402400035 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000295402400035 |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; airway inflammation; children's respiratory health; exhaled nitric oxide; traffic |
| Is Qa | No |