A novel model for prediction of human drug clearance by allometric scaling
Tang, H; Mayersohn, M
HERO ID
783476
Reference Type
Journal Article
Year
2005
Language
English
PMID
| HERO ID | 783476 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | A novel model for prediction of human drug clearance by allometric scaling |
| Authors | Tang, H; Mayersohn, M |
| Journal | Drug Metabolism and Disposition |
| Volume | 33 |
| Issue | 9 |
| Page Numbers | 1297-1303 |
| Abstract | Sixty-one sets of clearance (CL) values in animal species were allometrically scaled for predicting human clearance. Unbound fractions (f(u)) of drug in plasma in rats and humans were obtained from the literature. A model was developed to predict human CL: CL=33.35 ml/min x (a/Rf(u))(0.770), where Rf(u) is the f(u) ratio between rats and humans and a is the coefficient obtained from allometric scaling. The new model was compared with simple allometric scaling and the "rule of exponents" (ROE). Results indicated that the new model provided better predictability for human values of CL than did ROE. It is especially significant that for the first time the proposed model improves the prediction of CL for drugs illustrating large vertical allometry. |
| Doi | 10.1124/dmd.105.004143 |
| Pmid | 15958605 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |