Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water
Cirvello, JD; Radovsky, A; Heath, JE; Farnell, DR; Lindamood III, C
HERO ID
75829
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 75829 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water |
| Authors | Cirvello, JD; Radovsky, A; Heath, JE; Farnell, DR; Lindamood III, C |
| Journal | Toxicology and Industrial Health |
| Volume | 11 |
| Issue | 2 |
| Page Numbers | 151-165 |
| Abstract | T-Butyl alcohol (TBA) was administered in drinking water to F344/N rats and B6C3F1 mice for two years using 60 animals/dose/sex/species. Male rats received doses of 0. 1.25. 2.5. or 5 mg/ml and females received 0, 2.5, 5, or 10 mg/ml. resulting in average daily doses of approximately 85, 195, or 420 mg TBA/kg body weight for males and 175, 330, or 650 mg/kg for females. Ten rats per group were evaluated after 15 months. Male and female mice received doses of 0, 5, 10, or 20 mg/m, resulting in average daily doses of approximately 535, l,035, or 2.065 mg TBA/kg body weight for males and 510, 1,015, or 2,105 mg/kg for females. Survival was significantly reduced in male rats receiving 5mg/ml, female rats receiving 10 mg/ml, and male mice receiving 20 mg/ml. Long-term exposure to TBA produced increased incidences of renal tubule adenoma and carcinoma in male rats; transitional epithelial hyperplasia of the kidney in male and female rats; follicular cell adenoma of the thyroid in female mice: and follicular cell hvperplasia of the thyroid and inflammation and hyperplasia of the urinary bladder in male and female mice. In addition, a slight increase in follicular cell adenoma or carcinoma of the thyroid (combined) in male mice may have been related to the administration of TBA. |
| Doi | 10.1177/074823379501100203 |
| Pmid | 7491631 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. Italicize first t in t-butyl.Toxicol. Ind. Health 11: 151-165. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Body Weight/drug effects; Butanols/toxicity; Carcinogens/toxicity; Drinking; Female; Kidney Neoplasms/chemically induced/mortality; Male; Mice; Rats; Rats, Inbred F344; Thyroid Neoplasms/chemically induced/mortality; Urinary Bladder Diseases/chemically induced; tert-Butyl Alcohol; 0 (Butanols); 0 (Carcinogens); 75-65-0 (tert-Butyl Alcohol) |
| Is Qa | No |