DNA adducts of halogenated hydrocarbons
Bolt, HM; Laib, RJ; Peter, H; Ottenwälder, H
HERO ID
75345
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 75345 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | DNA adducts of halogenated hydrocarbons |
| Authors | Bolt, HM; Laib, RJ; Peter, H; Ottenwälder, H |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 112 |
| Issue | 2 |
| Page Numbers | 92-96 |
| Abstract | Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is some evidence for formation on an N-7 adduct of guanine which carries an ethyl-S-cysteinyl moiety. Extensive work has been published on adducts of vinyl chloride, both in vitro and in vivo. The major DNA adduct is 7-(2-oxoethyl)guanine; a minor adduct appears to be N2,3-ethenoguanine. Other etheno adducts, i.e., 1,N6-ethenoadenine and 3,N4-ethenocytosine, are readily formed with DNA, vinyl chloride, and a metabolizing system in vitro and with RNA in vivo, but are usually not detected as DNA adducts in vivo. The data on DNA alkylation by vinyl chloride (and vinyl bromide) metabolites are compared with those of structurally related compounds (acrylonitrile, vinyl acetate, vinyl carbamate). |
| Doi | 10.1007/BF00404388 |
| Pmid | 3771627 |
| Wosid | WOS:A1986E308900004 |
| Url | https://search.proquest.com/docview/77099974?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | J. Cancer Res. Clin. Oncol. 112: 92-96. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Methyl chloride; Methyl bromide; 1,2-Dichloroethane; 1,2-Dibromoethane; Vinyl chloride; Vinyl bromide; Vinylidene chloride; Trichloroethylene; Perchloroethylene; 2,2-Dichloro-diethyl ether; Acrylonitrile; Vinyl acetate; Vinyl carbamate |
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