Long-Term Exposure to Ambient Fine Particulate Matter () and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study
Guo, C; Hoek, G; Chang, LY; Bo, Y; Lin, C; Huang, B; Chan, TC; Tam, T; Lau, AKH; Lao, XQ
| HERO ID | 7496036 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Long-Term Exposure to Ambient Fine Particulate Matter () and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study |
| Authors | Guo, C; Hoek, G; Chang, LY; Bo, Y; Lin, C; Huang, B; Chan, TC; Tam, T; Lau, AKH; Lao, XQ |
| Journal | Environmental Health Perspectives |
| Volume | 127 |
| Issue | 12 |
| Page Numbers | 127008 |
| Abstract | <strong>BACKGROUND: </strong>The association between long-term exposure to ambient fine particulate matter with aerodynamic diameter () and lung function in young people remains uncertain, particularly in Asia, where air pollution is generally a serious problem.<br /><br /><strong>OBJECTIVES: </strong>This study investigated the association between long-term exposure to ambient and lung function in Taiwanese children, adolescents, and young adults.<br /><br /><strong>METHODS: </strong>This study comprised 24,544 participants 6-24 years of age, with 33,506 medical observations made between 2000 and 2014. We used a spatiotemporal model to estimate concentrations at participants' addresses. Spirometry parameters, i.e., forced vital capacity (FVC), forced expiratory volume in 1 s (), and maximum midexpiratory flow (MMEF), were determined. A generalized linear mixed model was used to examine the associations between long-term exposure to ambient and lung function. The odds ratios (ORs) of poor lung function were also calculated after adjusting for a range of covariates.<br /><br /><strong>RESULTS: </strong>Every increase in the 2-y average concentration was associated with decreases of 2.22% [95% confidence interval (CI): , ], 2.94 (95% CI: , ), and 2.79% (95% CI: , ) in the FVC, , and MMEF, respectively. Furthermore, it was associated with a 20% increase in the prevalence of poor lung function (OR: 1.20; 95% CI: 1.12, 1.29).<br /><br /><strong>CONCLUSIONS: </strong>Two-year ambient concentrations were inversely associated with lung function and positively associated with the prevalence of poor lung function in children, adolescents, and young adults in Taiwan. https://doi.org/10.1289/EHP5220. |
| Doi | 10.1289/EHP5220 |
| Pmid | 31873044 |
| Wosid | WOS:000505244800009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | No |
| Language Text | English |
| Is Peer Review | No |
| Is Qa | No |
| Relationship(s) |
|