Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function
Williams, R; Brook, R; Bard, R; Conner, T; Shin, H; Burnett, R
HERO ID
749285
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 749285 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function |
| Authors | Williams, R; Brook, R; Bard, R; Conner, T; Shin, H; Burnett, R |
| Journal | International Journal of Environmental Health Research |
| Volume | 22 |
| Issue | 1 |
| Page Numbers | 71-91 |
| Abstract | This work explored the association between nitrogen dioxide (NO(2)) and PM(2.5) components with changes in cardiovascular function in an adult non-smoking cohort. The cohort consisted of 65 volunteers participating in the US EPA's Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study. Systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), brachial artery flow-mediated dilatation (FMD) and nitroglycerin-mediated arterial dilatation (NMD) were collected by in-home examinations. A maximum of 336 daily environmental and health effect observations were obtained. Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) ± 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Personal NO(2) exposures resulted in significant changes in BAD (e.g., 0.0041 mm/ppb ± 0.0019, p = 0.0353, lag day 1) and FMD (0.0612 ± 0.0235, p = 0.0103, lag day 0) among other findings. |
| Doi | 10.1080/09603123.2011.588437 |
| Pmid | 21711166 |
| Wosid | WOS:000301792500007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000301792500007 |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollutant concentrations; exposure assessment; particulate matter; epidemiology |
| Is Qa | No |
| Relationship(s) |