Histopathological studies on the effect of phthalic acid esters on the biological system of mice
Ota, H; Onda, H; Kodama, H; Yamada, N
| HERO ID | 746780 |
|---|---|
| In Press | No |
| Year | 1974 |
| Title | Histopathological studies on the effect of phthalic acid esters on the biological system of mice |
| Authors | Ota, H; Onda, H; Kodama, H; Yamada, N |
| Journal | Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) |
| Volume | 29 |
| Issue | 5 |
| Page Numbers | 519-524 |
| Abstract | Oral administration of di-(2-ethylhexyl) phthalate (I) [117-81-7] and dibutyl phthalate (II) [84-74-2] in the diet for 1-3 months at 5.0 and 0.5 g/kg/day to mice resulted in marked lesions mostly in the liver and kidney. In the higher dose group, the liver showed remarkable vacuolar degeneration and necrosis of single cells, while the kidney showed cysts and degeneration of tubule epithelial cells. In the low dose group, degeneration of liver and kidney parenchyma was obsd. The cytotoxicity of I was greater than that of II. |
| Doi | 10.1265/jjh.29.519 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Nippon Eiseigaku Kaishi ISSN:Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016147116&doi=10.1265%2fjjh.29.519&partnerID=40&md5=64e99d63876143e2ac65fa18f13137f5 |
| Is Public | Yes |
| Language Text | Japanese |
| Keyword | phthalic acid derivative; phthalic acid dibutyl ester; autopsy; cell degeneration; dose response; drug response; drug toxicity; environmental health; epithelium cell; histology; intoxication; kidney; kidney injury; kidney tubule epithelium; liver; liver injury; liver necrosis; microscopy; mouse; oral drug administration; sheep; theoretical study; toxicity |