Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats
Nelson, BK; Brightwell, WS; Khan, A; Shaw, PB; Krieg, EF, Jr; Massari, VJ
| HERO ID | 732581 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats |
| Authors | Nelson, BK; Brightwell, WS; Khan, A; Shaw, PB; Krieg, EF, Jr; Massari, VJ |
| Journal | Pharmacopsychoecologia |
| Volume | 4 |
| Page Numbers | 1-7 |
| Abstract | Administered 2 concentrations of tertiary-butanol (t-butanol; 6,000 and 12,000 mg/m–3) by inhalation to groups of pregnant rats for 7 hrs/day on Gestation Days 1–29. Groups of male rats were similarily exposed for 7 hrs/day for 6 wks, and mated to unexposed females. From Days 10–90, offspring were tested for neuromotor coordination, activity, and learning. Results indicate that the high concentration of t-butanol was maternally toxic, reducing feed intake and maternal weight gain. Few differences, however, were found from controls in either the behavioral or neurochemical measures. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Nelson, B.K., W.S. Brightwell, A. Khan, P.B. Shaw, E. F. Krieg, Jr. and V.J. Massari. 1991. Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats. Pharmacopsychoecologia 4:1-7. |
| Is Public | Yes |
| Is Qa | No |