Occupational risk factors for cancer of the central nervous system (CNS) among US women
Cocco, P; Heineman, EF; Dosemeci, M
HERO ID
730500
Reference Type
Journal Article
Year
1999
Language
English
PMID
| HERO ID | 730500 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Occupational risk factors for cancer of the central nervous system (CNS) among US women |
| Authors | Cocco, P; Heineman, EF; Dosemeci, M |
| Journal | American Journal of Industrial Medicine |
| Volume | 36 |
| Issue | 1 |
| Page Numbers | 70-74 |
| Abstract | In a recent report, we found an elevated risk of cancer of the central nervous system (CNS) in several occupations and industries, and a modest association with exposure to solvents and to contact with the public.<br /><br /> To further explore the occupational risk of CNS cancer among women, we extended the analysis of the previous death certificate-based case-control study, including 12,980 female cases (ICD-9 codes 191 and 192) in 24 US states in 1984-1992 and 51,920 female controls who died from diseases other than malignancies and neurological disorders. We applied newly designed job-exposure matrices for 11 occupational hazards, previously reported as brain cancer risk factors, to the occupation and industry codes in the death certificates. We also conducted a separate analysis of 161 meningioma cases (ICD-9 codes 192.1 and 192.3), a tumor more frequent among women, particularly in the postmenopausal age group.<br /><br /> Overall, CNS cancer risk showed a 20-30% increase among women exposed to electromagnetic fields (EMF), methylene chloride, insecticides and fungicides, and contact with the public. Risk for meningioma was elevated among women exposed to lead (OR = 1.9; 95% CI 1.0, 3.9). CNS cancer did not show a clear pattern of risk increase by probability and intensity of exposure to any of the explored risk factors. Cross-classification by probability and intensity of exposure did not reveal any significant trend. Cases were too few to explore trends of meningioma by probability and intensity of exposure to lead.<br /><br /> We did not find evidence of a strong contribution of 11 occupational hazards to the etiology of CNS cancer. However, limitations of the occupational information might have reduced our ability to detect clear patterns of risk. |
| Doi | 10.1002/(SICI)1097-0274(199907)36:1<70::AID-AJIM10>3.0.CO;2-5 |
| Pmid | 10361589 |
| Wosid | WOS:000080624900010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | neoplasms; central nervous system; electromagnetic fields; solvents; pesticides; epidemiology; job-exposure matrices; women |
| Is Qa | No |