Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix
Brouwers, M; van Tongeren, M; Hirst, A; Bretveld, R; Roeleveld, N
HERO ID
699462
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 699462 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix |
| Authors | Brouwers, M; van Tongeren, M; Hirst, A; Bretveld, R; Roeleveld, N |
| Journal | Occupational and Environmental Medicine |
| Volume | 66 |
| Issue | 9 |
| Page Numbers | 607-614 |
| Abstract | The aim was to develop a new up-to-date and comprehensive job exposure matrix (JEM) for estimating exposure to potential endocrine disruptors in epidemiological research.<br /><br /> Chemicals with endocrine disrupting properties were identified from the literature and classified into 10 chemical groups: polycyclic aromatic hydrocarbons (PAHs), polychlorinated organic compounds, pesticides, phthalates, organic solvents, bisphenol A, alkylphenolic compounds, brominated flame retardants, metals and a miscellaneous group. Most chemical groups were divided into three to six subgroups. Focusing on the years 1996-2006, three experts scored the probability of exposure to each chemical group and subgroup for 353 job titles as "unlikely" (0), "possible" (1) or "probable" (2). Job titles with positive exposure probability scores were provided with exposure scenarios that described the reasoning behind the scores.<br /><br /> Exposure to any chemical group was unlikely for 238 job titles (67%), whereas 102 (29%) job titles were classified as possibly (17%) or probably (12%) exposed to one or several endocrine disruptors. The remaining 13 job titles provided too little information to classify exposure. PAHs, pesticides, phthalates, organic solvents, alkylphenolic compounds and metals were often linked to a job title in the JEM. The remaining chemical groups were found to involve very few occupations.<br /><br /> Despite some important limitations, this JEM could be a valuable tool for exposure assessment in studies on the health risks of endocrine disruptors, especially when task specific information is incorporated. The documented exposure scenarios are meant to facilitate further adjustments to the JEM to allow more widespread use. |
| Doi | 10.1136/oem.2008.042184 |
| Pmid | 19286684 |
| Wosid | WOS:000269063400008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: International Agency for Research on Cancer (IARC)Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-69949085069&doi=10.1136%2foem.2008.042184&partnerID=40&md5=b8da7454d660f71ed073242a977704fa |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>chemical products</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>endocrine effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>exposure evaluation</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>job-exposure relation</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>aromatic hydrocarbons</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>bisphenol A</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>brominated organic compounds</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>classification</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>epidemiology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>flame retardants</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>literature survey</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>metals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>organic solvents</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>pesticides</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>phenols</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>phthalates</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>polycyclic hydrocarbons</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxic and dangerous substances</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chemical safety</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Periodical articles</kw> |
| Is Qa | No |