Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: A HuGE review
Minelli, C; Wei, I; Sagoo, G; Jarvis, D; Shaheen, S; Burney, P
HERO ID
697278
Reference Type
Journal Article
Subtype
Review
Year
2011
Language
English
PMID
| HERO ID | 697278 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2011 |
| Title | Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: A HuGE review |
| Authors | Minelli, C; Wei, I; Sagoo, G; Jarvis, D; Shaheen, S; Burney, P |
| Journal | American Journal of Epidemiology |
| Volume | 173 |
| Issue | 6 |
| Page Numbers | 603-620 |
| Abstract | Susceptibility to the respiratory effects of air pollution varies between individuals. Although some evidence suggests higher susceptibility for subjects carrying variants of antioxidant genes, findings from gene-pollution interaction studies conflict in terms of the presence and direction of interactions. The authors conducted a systematic review on antioxidant gene-pollution interactions which included 15 studies, with 12 supporting the presence of interactions. For the glutathione S-transferase M1 gene (GSTM1) (n = 10 studies), only 1 study found interaction with the null genotype alone, although 5 observed interactions when GSTM1 was evaluated jointly with other genes (mainly NAD(P)H dehydrogenase [quinone] 1 (NQO1)). All studies on the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism (n = 11) provided some evidence of interaction, but findings conflicted in terms of risk allele. Results were negative for glutathione S-transferase T1 (GSTT1) (n = 3) and positive for heme oxygenase 1 (HMOX-1) (n = 2). Meta-analysis could not be performed because there were insufficient data available for any specific gene-pollutant-outcome combination. Overall the evidence supports the presence of gene-pollution interactions, although which pollutant interacts with which gene is unclear. However, issues regarding multiple testing, selective reporting, and publication bias raise the possibility of false-positive findings. Larger studies with greater accuracy of pollution assessment and improved quality of conduct and reporting are required. |
| Doi | 10.1093/aje/kwq403 |
| Pmid | 21343247 |
| Wosid | WOS:000288274800002 |
| Url | https://www.proquest.com/scholarly-journals/interactive-effects-antioxidant-genes-air/docview/861612251/se-2 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000288274800002 |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution; antioxidants; epidemiology; genetics; genome; human; genotype-environment interaction; respiratory system; review |
| Is Qa | No |