Deposition and clearance of inhaled particles
Schlesinger, RB
HERO ID
6865
Reference Type
Book/Book Chapter
Year
1995
Language
English
| HERO ID | 6865 |
|---|---|
| Year | 1995 |
| Title | Deposition and clearance of inhaled particles |
| Book Title | Concepts in inhalation toxicology |
| Authors | Schlesinger, RB |
| Editor | McClellan, RO; Henderson, RF |
| Publisher Text | Taylor & Francis |
| City | Washington, DC |
| Page Numbers | 191-224 |
| Abstract | I. The biologic effects of inhaled particles are a function of their disposition. This, in turn, depends upon their patterns of deposition, i.e., the sites within which they initially come into contact with airway epithelial surfaces and the amounts removed from the inhaled air at these sites, and clearance, i.e., the rates and routes by which deposited particles are physically removed from the respiratory tract. For materials, such as irritants, which exert their action upon surface contact, the initial deposition is the predicator of toxic response. In many other cases, however, it is the net result of deposition and clearance--namely retention, i.e., the amount of particles remaining in the respiratory tract at specific times after exposure--which influences toxicity This chapter provides an overview of the processes by which airborne particles are deposited within and cleared from the respiratory tract. |
| Is Certified Translation | No |
| Dupe Override | No |
| Isbn | 9781560323686 |
| Edition | 2 |
| Comments | ECRIB. NCEA TRC has 1988 version (RC732.C66) |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |