Lung clearance of inhaled insoluble and soluble particles
Oberdörster, G
| HERO ID | 6857 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Lung clearance of inhaled insoluble and soluble particles |
| Authors | Oberdörster, G |
| Journal | Journal of Aerosol Medicine |
| Volume | 1 |
| Issue | 4 |
| Page Numbers | 289-330 |
| Abstract | National Institute of Environmental Health Sciences. INTRODUCTION: Efficient elimination of inhaled soluble and insoluble particulate compounds deposited in the respiratory tract is necessary to keep its mucosal surfaces clean and functionally intact. In addition, the characteristic clearance processes and kinetics prevailing in different regions of the respiratory tract determine the retained dose of an inhaled substance in structures of the respiratory system. Thus, whether deposition and subsequent retention of inhaled particles is considered in clinical situations involving diagnostic or therapeutic aerosols or in toxicology with occupational or environmental pollutant aerosols, knowledge of the clearance of these substances is crucial in understanding their respiratory tract dosimetry. Clearance mechanisms are not only different for different regions of the respiratory tract, but also depend on physico-chemical characteristics of the deposited particulate material. Several recent review articles provide detailed descriptions and discussions of different processes governing the removal of inhaled solid and solute particles after deposition in the respiratory tract (Lauweryns and Baert, 1977; Morrow, 1977; Camner, 1980; Jones et al., 1982; Effros and Mason, 1983; Jones, 1984; Pavia, 1984; Morrow and Yu, 1985; Schlesinger, 1985; Brain, 1985, 1986; Cuddihy and Yeh, 1988). Because of the multitude and complexity of the diverse respiratory tract clearance processes, the present article will selectively review aspects of soluble and insoluble particle removal from tracheobronchial and deep lung regions. In addition, the article emphasizes clinical and toxicological implications of these removal processes and considers some unresolved issues related to lung clearance. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. Umlaut over 2nd o in Oberdorster.J. Aerosol Med. 1: 289-330. |
| Is Public | Yes |
| Is Qa | No |