Toxicology of diethylene glycol butyl ether: 3 genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenetic test
Gollapudi, BB; Linscombe, VA; Mcclintock, ML; Sinha, AK; Stack, CR
| HERO ID | 68439 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Toxicology of diethylene glycol butyl ether: 3 genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenetic test |
| Authors | Gollapudi, BB; Linscombe, VA; Mcclintock, ML; Sinha, AK; Stack, CR |
| Journal | International Journal of Toxicology |
| Volume | 12 |
| Issue | 2 |
| Page Numbers | 155-159 |
| Abstract | DGBE was evaluated in a forward gene mutation assay at the HGPRT locus of CHO cells in culture and in an in vivo mouse bone marrow micronucleus test for cytogenetic damage. DGBE did not elicit a positive response in the CHO/HGPRT assay when tested up to a maximum concentration of 5000 mu g/ml with and without and external metabolic activation system (S-9). In the micronucleus test employing three post-treatment bone marrow sampling times (24, 48 and 72 hr), DGBE was ineffective in increasing the incidence of micronucleated polychromatic erythrocytes (MN-PCE) when tested in both sexes up to a maximum tolerated dose of 3300 mg/kg body weight. Thus, these data and those of others indicate a general lack of genotoxic potential for DGBE in short-term tests. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | in vitro and in vivo are italicized.J. Am. Coll. Toxicol. 12: 155-159. |
| Is Public | Yes |
| Language Text | English |
| Keyword | genotoxicity in vitro in vivo CHO cells bone marrow |
| Is Qa | No |