n-Butyl acetate
| HERO ID | 672910 |
|---|---|
| Year | 2001 |
| Title | n-Butyl acetate |
| Book Title | Documentation of the threshold limit values and biological exposure indices |
| Authoring Organization | American Conference of Governmental Industrial Hygienists |
| Publisher Text | American Conference of Governmental Industrial Hygienists |
| City | Cincinnati, OH |
| Page Numbers | 7 |
| Abstract | In experiments with the atomization of n-butyl acetate in chambers with rats, the LC50 was as low as 156 ppm.(4) However, workplace exposures occur almost universally to n-butyl acetate vapor, and direct exposure to atomized n-butyl acetate exposure did not occur in occupational situations.^ Accordingly, the marked toxicity of the atomized n-butyl acetate observed in animal bioassays is not of practical concern in the workplace. A TLV-TWA of 150 ppm is recommended for n-butyl acetate to minimize the potential risk of eye and mucous membrane irritation reported in volunteers exposed at 200 to 300 ppm of n-butyl acetate for 3 to 20 minutes.(35,37) A TLV-STEL of 200 ppm is recommended to control the excursions that produced mucous membrane irritation in the volunteers at exposures of 200 to 300 ppm for 3 to 20 minutes.(35,37) Given the high vapor pressure of this compound and the fact that topical application of n-butyl acetate in rabbits(27) and guinea pigs(20) failed to elicit systemic toxicity, the skin notation is not warranted Sufficient data were not available to recommend SEN or carcinogenicity notations. The reader is expected to be familiar with the section on Excursion Limits in the "Introduction to the Chemical Substance TLVs" of the current edition of the Documentation of the TLVs and BEIs for the guidance and control of excursions above the TLV-TWA, even when the 8-hour TWA is within the recommended limit. |
| Is Certified Translation | No |
| Dupe Override | No |
| Edition | 7th |
| Is Public | Yes |
| Is Qa | No |