Biochemical studies of promoters of carcinogenesis in rat liver
Kitchin, KT; Brown, JL
HERO ID
669212
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 669212 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Biochemical studies of promoters of carcinogenesis in rat liver |
| Authors | Kitchin, KT; Brown, JL |
| Journal | Teratogenesis, Carcinogenesis, and Mutagenesis |
| Volume | 9 |
| Issue | 5 |
| Page Numbers | 273-285 |
| Abstract | Adult female rats were orally dosed with 1/5 to 3/5 the published LD50 of either promoters or putative promoters of carcinogenesis [hexachlorobenzene (HCB), alpha-hexachlorocyclohexane (alpha-HCH), kepone and toxaphene] or noncarcinogens [coumaphos, EDTA, caprolactam, 8-hydroxyquinoline, titanium (IV) oxide, sodium diethyldithiocarbamate (DEDTC), and sucrose] at 21 and 4 h before sacrifice. The promoters selected in this study were all of the halogenated hydrocarbon class. At doses of 1/5 to 3/5 the LD50, all four promoters or putative promoters induced rat hepatic ODC activity. The seven noncarcinogens produced several biochemical effects at doses of 1/5 the LD50: increased serum alanine aminotransferase activity (SGPT) (caprolactam and DEDTC), decreased hepatic cytochrome P-450 content (DEDTC), and increased hepatic ODC activity (8-hydroxyquinoline and DEDTC). None of the seven noncarcinogens caused hepatic DNA damage or coordinate induction of hepatic ODC and cytochrome P-450. The results support the interpretation that several of these biochemical parameters are useful in distinguishing potential tumor promoters and noncarcinogens. |
| Doi | 10.1002/tcm.1770090503 |
| Pmid | 2575289 |
| Wosid | WOS:A1989CB32900002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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