Inverse probability weighted distributed lag effects of short-term exposure to PM2.5 and ozone on CVD hospitalizations in New England Medicare participants - Exploring the causal effects
Qiu, X; Wei, Y; Wang, Y; Di, Q; Sofer, T; Awad, YA; Schwartz, J
HERO ID
6671790
Reference Type
Journal Article
Year
2020
Language
English
PMID
| HERO ID | 6671790 |
|---|---|
| In Press | No |
| Year | 2020 |
| Title | Inverse probability weighted distributed lag effects of short-term exposure to PM2.5 and ozone on CVD hospitalizations in New England Medicare participants - Exploring the causal effects |
| Authors | Qiu, X; Wei, Y; Wang, Y; Di, Q; Sofer, T; Awad, YA; Schwartz, J |
| Journal | Environmental Research |
| Volume | 182 |
| Issue | Elsevier |
| Page Numbers | 109095 |
| Abstract | <strong>BACKGROUND: </strong>Although many studies have established significant associations between short-term air pollution and the risk of getting cardiovascular diseases, there is a lack of evidence based on causal distributed lag modeling.<br /><br /><strong>METHODS: </strong>Inverse probability weighting (ipw) propensity score models along with conditional logistic outcome regression models based on a case-crossover study design were applied to get the causal unconstrained distributed (lag0-lag5) as well as cumulative lag effect of short-term exposure to PM2.5/Ozone on hospital admissions of acute myocardial infarction (AMI), congestive heart failure (CHF) and ischemic stroke (IS) among New England Medicare participants during 2000-2012. Effect modification by gender, race, secondary diagnosis of Chronic Obstructive Pulmonary Diseases (COPD) and Diabetes (DM) was explored.<br /><br /><strong>RESULTS: </strong>Each 10 μg/m3 increase in lag0-lag5 cumulative PM2.5 exposure was associated with an increase of 4.3% (95% confidence interval: 2.2%, 6.4%, percentage change) in AMI hospital admission rate, an increase of 3.9% (2.4%, 5.5%) in CHF rate and an increase of 2.6% (0.4%, 4.7%) in IS rate. A weakened lagging effect of PM2.5 from lag0 to lag5 could be observed. No cumulative short-term effect of ozone on CVD was found. People with secondary diagnosis of COPD, diabetes, female gender and black race are sensitive population.<br /><br /><strong>CONCLUSIONS: </strong>Based on our causal distributed lag modeling, we found that short-term exposure to an increased ambient PM2.5 level had the potential to induce higher risk of CVD hospitalization in a causal way. More attention should be paid to population of COPD, diabetes, female gender and black race. |
| Doi | 10.1016/j.envres.2019.109095 |
| Pmid | 31927244 |
| Wosid | WOS:000516094400119 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/S0013935119308916 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Ambient air pollution; CVD; Causal modeling; Distributed lag; Medicare |