The effect of arsenic on urethan-induced adenoma formation in Swiss mice
Blakley, BR
HERO ID
65320
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 65320 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | The effect of arsenic on urethan-induced adenoma formation in Swiss mice |
| Authors | Blakley, BR |
| Journal | Canadian Journal of Veterinary Research |
| Volume | 51 |
| Issue | 2 |
| Page Numbers | 240-243 |
| Abstract | Female Swiss mice were exposed to sodium arsenite or sodium aresenate in the drinking water for 15 weeks at concentrations ranging from 0 to 100 micrograms/mL arsenic content. After three weeks of the 15 week exposure period, the mice were administered urethan (1.5 mg/g) intraperitoneally. Pulmonary adenoma formation was evaluated 12 weeks later. Arsenic exposure produced a protective effect with respect to tumor development. Both forms of arsenic reduced the size and number of pulmonary adenomas observed per mouse. In addition, urethan-induced sleeping times which reflect the rate of urethan metabolism or excretion remained unchanged. This suggests that arsenic exposure does not alter urethan excretion and is not a factor influencing subsequent adenoma formation of these levels of exposure. |
| Pmid | 3607654 |
| Wosid | WOS:A1987J911700017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1987J911700017 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-Environmental and Industrial Toxicology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Public Health: Environmental Health-Air</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Veterinary Science-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |
| Relationship(s) |
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