Experimental respiratory carcinogenesis in small laboratory animals
Pepelko, WE
| HERO ID | 65308 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Experimental respiratory carcinogenesis in small laboratory animals |
| Authors | Pepelko, WE |
| Journal | Environmental Research |
| Volume | 33 |
| Issue | 1 |
| Page Numbers | 144-188 |
| Abstract | Procedures for conducting experimental studies of respiratory carcinogenesis are reviewed. Advantages and disadvantages of mice, rats, or hamsters in studies of respiratory carcinogenesis are assessed. Mice have the advantage of small size and short life span; hamsters are resistant to pulmonary infection, have a low spontaneous lung tumor incidence, and develop tumors similar to those of humans; and rats are sensitive to induction of nasal cancer by organic chemicals. Oncogenic responses from inhalation of organic chemicals are tabulated. Chemicals studied include: acetaldehyde (75070), acrylonitrile (107131), acrolein (107028), benzo(a)pyrene (50328), benzene (71432), bis(chloromethyl)ether (542881), chloromethylmethylether (107302), diazomethane (334883), 1,2-dibromo-3-chloropropane (96128), dichloroethylene (25323302), dimethylcarbamoylchloride (79447), epichlorohydrin (106898), ethylene-dibromide (106934), furfural (98011), ethylene-oxide (75218), formaldehyde (50000), hexamethyl-phosphoramide (680319), methylcholanthrene (56495), urethane (51796), polyurethane (9009545), tetrachloroethylene (127184), trichloroethylene (79016), vinyl-bromide (593602), and vinyl-chloride (75014). Oncogenic responses from inhalation of metallic and nonmetallic compounds are presented. Induction of respiratory tract tumors by cigarette smoke inhalation, ambient air and smog, engine emissions, fossil fuel derived smoke and fumes, dusts and solid aerosols, and liquid aerosols is discussed. The author concludes that despite the limitations in the use of animal inhalation experiments to predict the likelihood of cancer induction in humans, there are no clear cut better alternatives at present. Long term inhalation studies are likely to continue with the aid of new strains that more closely resemble human tumor types, pharmacokinetic factors, and metabolic processes. |
| Doi | 10.1016/0013-9351(84)90015-X |
| Pmid | 6198173 |
| Wosid | WOS:A1984SC65800014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Environ. Res. 33: 144-188. |
| Is Public | Yes |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-131190</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory irritants</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lung irritants</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lung fibrosis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lung burden</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lung disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Breathing</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory rate</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogenicity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogens</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Lung</kw> |
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