Toxicological review of carbon tetrachloride (CASRN 56-23-5) in support of summary information on the Integrated Risk Information System (IRIS)
HERO ID
647315
Reference Type
Technical Report
Subtype
EPA Report
Year
2010
Language
English
| HERO ID | 647315 |
|---|---|
| Material Type | EPA Report |
| Year | 2010 |
| Title | Toxicological review of carbon tetrachloride (CASRN 56-23-5) in support of summary information on the Integrated Risk Information System (IRIS) |
| Authoring Organization | U.S. Environmental Protection Agency |
| Publisher Text | U.S. Environmental Protection Agency |
| City | Washington, DC |
| Volume | GRA and I |
| Abstract | This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of carbon tetrachloride. IRIS Summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal of entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). |
| Report Number | EPA/635/R-08/005F |
| Url | http://www.epa.gov/iris/toxreviews/0020tr.pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 473 |
| Comments | ICF NOTE: 1097-CarbTet-3.pdf |
| Is Public | Yes |
| Language Text | English |
| Keyword | Toxicity; Carbon tetrachloride; Health effects; Risk assessment; Environmental exposure; Health hazards; Carcinogens; Chemical properties; Inhalation; Respiratory system; Integrated Risk Information System (IRIS); 56-23-5 |
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