Effects of aliphatic chlorohydrocarbons on drug-metabolizing enzymes in rat liver in vivo
Vainio, H; Parkki, MG; Marniemi, J
HERO ID
64426
Reference Type
Journal Article
Year
1976
Language
English
PMID
| HERO ID | 64426 |
|---|---|
| In Press | No |
| Year | 1976 |
| Title | Effects of aliphatic chlorohydrocarbons on drug-metabolizing enzymes in rat liver in vivo |
| Authors | Vainio, H; Parkki, MG; Marniemi, J |
| Journal | Xenobiotica |
| Volume | 6 |
| Issue | 10 |
| Page Numbers | 599-604 |
| Abstract | 1. Various polychlorinated hydrocarbons were administered intragastrically to rats to examine their effects on the biotransformation capacity of the liver. Due to high toxicity, 1,1,2,2-tetrachloroethane and pentachloroethane were given at a dose level equivalent to one quarter of that of CCl4 and the other chlorohydrocarbons (i.e. 2-6 mmol/kg). 2. Carbon tetrachloride at 10-3 mmol/kg was the most active in decreasing cytochrome P-450 content and the overall drug hydroxylation activities in rat liver. 1,1,2,2-Tetrachloroethane was the next most active in decreasing the hepatic drug oxidizing enzymic activities. 3. Expoxide hydratase activity in rat liver declined significantly after CCl4, 1,1,2,2-tetrachloroethane and pentachloroethane administrations. 4. UDP-Glucuronosyltransferase was affected to a lesser extent than the microsomal mono-oxygenase or epoxide hydratase by chlorohydrocarbon treatment. |
| Doi | 10.3109/00498257609151673 |
| Pmid | 824867 |
| Url | http://www.tandfonline.com/doi/full/10.3109/00498257609151673 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |