The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat
Jones, AR; Fakhouri, G; Gadiel, P
| HERO ID | 63497 |
|---|---|
| In Press | No |
| Year | 1979 |
| Title | The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat |
| Authors | Jones, AR; Fakhouri, G; Gadiel, P |
| Journal | Cellular and Molecular Life Sciences (CMLS) |
| Volume | 35 |
| Issue | 11 |
| Page Numbers | 1432-1434 |
| Abstract | The soil fumigant 1,2-dibromo-3-chloropropane (I) undergoes hydrolysis in the rat to a series of epoxide metabolites. Alkylation of glutathione by these epoxides produces 2 urinary metabolites identified as the mercapturic acids VI (R=COCH3) and VII (R-COCH3). Hydrolysis of the epoxides produces the male antifertility agents alpha-chlorohydrin (IX, X-Cl) and alpha-bromohydrin (IX, X-Br) which are oxidatively metabolized to oxalic acid (XII), thus causing renal damage. These metabolic pathways can explain the toxic nature of the fumigant as a carcinogen, a male chemosterilant and as an agent causing kidney damage. |
| Doi | 10.1007/BF01962767 |
| Pmid | 510467 |
| Wosid | WOS:A1979HV11400013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Experientia 35: 1432-1434. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |