The metabolism of carbaryl in the rat, guinea pig, and man
Knaak, JB; Tallant, MJ; Bartley, WJ; Sullivan, LJ
| HERO ID | 63342 |
|---|---|
| In Press | No |
| Year | 1965 |
| Title | The metabolism of carbaryl in the rat, guinea pig, and man |
| Authors | Knaak, JB; Tallant, MJ; Bartley, WJ; Sullivan, LJ |
| Journal | Journal of Agricultural and Food Chemistry |
| Volume | 13 |
| Issue | 6 |
| Page Numbers | 537-543 |
| Abstract | The metabolic fate of methyl-C14, carbonyl-C14, and naphthyl-C14 carbaryl in the rat and guinea pig was investigated. The over-all recovery of the naphthyl, carbonyl, and methyl label was, respectively, 95, 99, and 91% of dose. Tissue residues (2 to 3% of dose) were found only in the case of methyl-labeled carbaryl. The metabolites identified were 4-(methylcarbamoyloxy)-l -naphthyl glucuronide, 1-naphthyl glucuronide, 4-(methylcarbamoyloxy)-l -naphthyl sulfate, and 1-naphthyl sulfate. Evidence is presented for the possible direct conjugation of carbaryl with glucuronic acid to form 1-naphthyl methyl carbamate N-glucuronide and 1-naphthyl methylimidocarbonate O-glucuronide. The assay of carbaryl, carbaryl derivatives, and metabolites in water by fluorometry was investigated in conjunction with C14 chromatographic studies and the method applied to the analysis of urines from men exposed to carbaryl dust. The only detectable metabolites present were 1-naphthyl glucuronide and sulfate. © 1965, American Chemical Society. All rights reserved. |
| Doi | 10.1021/jf60142a014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | J. Agric. Food Chem. 13: 537-543.Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0344400412&doi=10.1021%2fjf60142a014&partnerID=40&md5=710c779f293c2cb4bc06155a27c41837 |
| Is Public | Yes |
| Language Text | English |