Hexachloroethane: Tissue clearance and distribution in Fischer 344 rats
Nolan, RJ; Karbowski, RJ
| HERO ID | 63257 |
|---|---|
| Year | 1978 |
| Title | Hexachloroethane: Tissue clearance and distribution in Fischer 344 rats |
| Authors | Nolan, RJ; Karbowski, RJ |
| Publisher Text | Dow Chemical Company, Toxicology Research Laboratory |
| City | Midland, MI |
| Abstract | The distribution and elimination of hexachloroethane (HCE) was evaluated in male and female Fischer 344 rats after oral ingestion of the test material. The rate at which HEC is cleared from tissue was evaluated in twenty male rats after receiving the test material for 57 days in the diet at a estimated concentration of 100mg/kg/day. Three to four animals were sacrificed 0, 3, 6, 13, 22 and 33 days after the last day of treatment. Fat, liver, kidney and whole blood were taken for analysis. The highest concentration of HCE was found in the fat (303 +/- 50 ug/g). The concentration of HCE in the fat was approximately three times the concentration found in the kidney, and over 100 times that found in the liver and blood. HEC cleared from the fat, liver, kidney and blood in an apparent first order manner, with half-lives between 2-3 days. A second experiment evaluated the concentration of HCE in the tissues of male and female rats (4/sex/group) after receiving the test material for 111 days in the diet at a estimated concentration of 3, 30 or 100mg/kg/day. The concentration of HCE in the male kidneys was higher than the female kidneys and the difference was most noticeable at the high dose level. As the dose rate increased, the relative increases in the levels of HCE was greater in the fat and less in the liver for both sexes. |
| Report Number | 878213746 |
| Ntis Number | OTS0206444 |
| Url | https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=OTS0206444 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | NTIS bundled this report together with "The irritant action of hexachloroethane with cover letter" |
| Is Public | Yes |
| Is Qa | No |