Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat
Huo, J-Z; Aldous, S; Campbell, K; Davies, N
HERO ID
631257
Reference Type
Journal Article
Year
1989
Language
English
PMID
| HERO ID | 631257 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat |
| Authors | Huo, J-Z; Aldous, S; Campbell, K; Davies, N |
| Journal | Xenobiotica |
| Volume | 19 |
| Issue | 2 |
| Page Numbers | 161-170 |
| Abstract | 1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies. 2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident. 3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period. 4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethylhippuric acid (30.2% dose), 2,4-dimethylbenzyl alcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates). |
| Doi | 10.3109/00498258909034688 |
| Pmid | 2728490 |
| Wosid | WOS:A1989T379200004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Administration, Oral; Animals; Arylsulfatases/metabolism; Benzene Derivatives/metabolism/pharmacokinetics/urine; Carbon Radioisotopes/diagnostic use; Gas Chromatography-Mass Spectrometry; Glucuronates/urine; Glucuronidase/metabolism; Hydrolysis; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Sulfates/urine; 0 (Benzene Derivatives); 0 (Carbon Radioisotopes); 0 (Glucuronates); 0 (Sulfates); 95-63-6 (pseudocumene); EC 3.1.6.1 (Arylsulfatases); EC 3.2.1.31 (Glucuronidase) |
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