Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats
Richmond, RE; Carter, JH; Carter, HW; Daniel, FB; Deangelo, AB
HERO ID
630920
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 630920 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Immunohistochemical analysis of dichloroacetic acid (DCA)-induced hepatocarcinogenesis in male Fischer (F344) rats |
| Authors | Richmond, RE; Carter, JH; Carter, HW; Daniel, FB; Deangelo, AB |
| Journal | Cancer Letters |
| Volume | 92 |
| Issue | 1 |
| Page Numbers | 67-76 |
| Abstract | We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21 ras, p39 c-jun, p55 c-fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat. |
| Doi | 10.1016/0304-3835(94)03756-9 |
| Pmid | 7538896 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/0304383594037569 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Dichloroacetic acid; Experimental hepatocarcinogenesis; p21 ras; p39 c-jun; p55 c-fos; Aldehyde dehydrogenase; Glutathione s-transferase; Alpha fetoprotein |
| Is Qa | No |