Induction of single-strand breaks in dna of mice by trichloroethylene and tetrachloroethylene
Walles, SAS
HERO ID
629915
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 629915 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Induction of single-strand breaks in dna of mice by trichloroethylene and tetrachloroethylene |
| Authors | Walles, SAS |
| Journal | Toxicology Letters |
| Volume | 31 |
| Issue | 1 |
| Page Numbers | 31-35 |
| Abstract | Trichloroethylene (TRI) (4–10 mmol/kg body wt) and tetrachloroethylene (PER) (4–8 mmol/kg body wt) were given to male mice by i.p. injection. The induction of single-strand breaks (SSB) in DNA of liver, kidney and lung was studied by the DNA unwinding technique. There was a linear increase of the level of SSB in kidney and liver DNA but not in lung DNA l h after administration. The damage was completely repaired 24 h after injection. The capability of TRI and PER to induce SSB in liver DNA is compared to that of three other substances, i.e., methyl methanesulfonate (MMS), styrene-7,8-oxide and styrene, which have been studied earlier by the same technique. The potency of the substances for induction of SSB was in the following order: MMS > styrene-7,8-oxide > styrene > PER > TRI. |
| Doi | 10.1016/0378-4274(86)90191-8 |
| Pmid | 3715914 |
| Wosid | WOS:A1986C658300005 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022538708&doi=10.1016%2f0378-4274%2886%2990191-8&partnerID=40&md5=510425cdc74f31e122a2e219a4b1cdf4 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: TOXICOL LETT 31 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Trichloroethylene; tetrachloroethylene; DNA; single-strand breaks |
| Is Qa | No |
| Relationship(s) |
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