Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells
Ochi, T; Kaise, T; Oya-Ohta, Y
HERO ID
627808
Reference Type
Journal Article
Year
1994
Language
English
PMID
| HERO ID | 627808 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells |
| Authors | Ochi, T; Kaise, T; Oya-Ohta, Y |
| Journal | Experientia |
| Volume | 50 |
| Issue | 2 |
| Page Numbers | 115-120 |
| Abstract | The cytotoxicity of arsenic compounds towards BALB/c 3T3 cells in culture was investigated, together with the role of glutathione (GSH) in the induction of the cytotoxic effects. The rank order of cytotoxicity was as follows: arsenite (As3+) > arsenate (As5+) > dimethylarsinic acid (DMAA) > methylarsonic acid (MAA) > trimethylarsine oxide (TMAO). Arsenobetaine, arsenocholine and the tetramethylarsonium ion were less toxic. Depletion of GSH enhanced the cytotoxic effects of As3+, As5+, MAA and TMAO, while the cytotoxicity of DMAA was markedly reduced by depletion of GSH. These results suggest that GSH plays a role in protecting the cells against the toxic effects of As3+, As5+, MAA and TMAO while it is involved in the induction of the cytotoxic effects of DMAA. |
| Doi | 10.1007/BF01984946 |
| Pmid | 8125168 |
| Wosid | WOS:A1994MW47600008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | |WOS:A1994MW47600008 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Arsenic compounds; cytotoxicity; BALB/c 3T3 cells; glutathione depletion |
| Is Qa | No |