Cytogenetic effects in human exposure to arsenic
Gonsebatt, ME; Vega, L; Salazar, AM; Montero, R; Guzmán, P; Blas, J; Del Razo, LM; García-Vargas, G; Albores, A; Cebrián, ME; Kelsh, M; Ostrosky-Wegman, P
HERO ID
627248
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 627248 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Cytogenetic effects in human exposure to arsenic |
| Authors | Gonsebatt, ME; Vega, L; Salazar, AM; Montero, R; Guzmán, P; Blas, J; Del Razo, LM; García-Vargas, G; Albores, A; Cebrián, ME; Kelsh, M; Ostrosky-Wegman, P |
| Journal | Mutation Research |
| Volume | 386 |
| Issue | 3 |
| Page Numbers | 219-228 |
| Abstract | The cytogenetic effects of arsenic exposure were studied among rural populations that live in the same geographical area and have similar socioeconomic status, but different degree of exposure to inorganic arsenic (As) via drinking water. A group of inhabitants of Santa Ana (408.17 micrograms/l of As in drinking water) were considered the exposed individuals and a group of inhabitants of Nazareno (29.88 micrograms/l) were considered as controls. Blood and urine samples were obtained from volunteers. Past and current exposure, health, and nutritional status as well as the presence of arsenic skin lesions were ascertained in study participants through questionnaires and physical examination. The frequencies and types of chromosomal aberrations in first-division metaphases were studied in whole blood lymphocyte cultures while the presence of micronuclei (MN) was studied in exfoliated epithelial cells obtained from the oral mucosa and from urine samples. Total arsenic (TAs) content, and the relative proportions of inorganic arsenic (IAs), and the metabolites monomethylarsonic (MMA) and dimethylarsinic (DMA) acid were determined in urine samples. Exposed individuals showed a significant increase in the frequency of chromatid and isochromatid deletions in lymphocytes and of MN in oral and urinary epithelial cells. Males were more affected than females, and a higher number of micronucleated oral cells were found among those individuals with skin lesions. The type of cytogenetic damage observed gives evidence of arsenic as a clastogenic/aneugenic carcinogen. |
| Doi | 10.1016/S1383-5742(97)00009-4 |
| Pmid | 9219560 |
| Wosid | WOS:A1997XG03500005 |
| Url | http://linkinghub.elsevier.com/retrieve/pii/S1383574297000094 |
| Is Certified Translation | No |
| Dupe Override | 627248 |
| Comments | |WOS:A1997XG03500005 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-240005</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metalloids</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Environmental exposure</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Drinking water</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Humans</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Arsenic poisoning</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Genotoxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Skin lesions</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Bladder tissue</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Chromosome disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Epidemiology</kw> |
| Is Qa | No |