Association of early-life exposure to household gas appliances and indoor nitrogen dioxide with cognition and attention behavior in preschoolers
Morales, E; Julvez, J; Torrent, M; de Cid, R; Guxens, M; Bustamante, M; Künzli, N; Sunyer, J
HERO ID
625909
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 625909 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Association of early-life exposure to household gas appliances and indoor nitrogen dioxide with cognition and attention behavior in preschoolers |
| Authors | Morales, E; Julvez, J; Torrent, M; de Cid, R; Guxens, M; Bustamante, M; Künzli, N; Sunyer, J |
| Journal | American Journal of Epidemiology |
| Volume | 169 |
| Issue | 11 |
| Page Numbers | 1327-1336 |
| Abstract | The authors investigated the association of early-life exposure to indoor air pollution with neuropsychological development in preschoolers and assessed whether this association differs by glutathione-S-transferase gene (GSTP1) polymorphisms. A prospective, population-based birth cohort was set up in Menorca, Spain, in 1997–1999 (n = 482). Children were assessed for cognitive functioning (McCarthy Scales of Children's Abilities) and attention-hyperactivity behaviors (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) at age 4 years. During the first 3 months of life, information about gas appliances at home and indoor nitrogen dioxide concentration was collected at each participant's home (n = 398, 83%). Genotyping was conducted for the GSTP1 coding variant Ile105Val. Use of gas appliances was inversely associated with cognitive outcomes (β coefficient for general cognition = –5.10, 95% confidence interval (CI): –9.92, –0.28; odds ratio for inattention symptoms = 3.59, 95% CI: 1.14, 11.33), independent of social class and other confounders. Nitrogen dioxide concentrations were associated with cognitive function (a decrease of 0.27 point per 1 ppb, 95% CI: –0.48, –0.07) and inattention symptoms (odds ratio = 1.06, 95% CI: 1.01, 1.12). The deleterious effect of indoor pollution from gas appliances on neuropsychological outcomes was stronger in children with the GSTP1 Val-105 allele. Early-life exposure to air pollution from indoor gas appliances may be negatively associated with neuropsychological development through the first 4 years of life, particularly among genetically susceptible children. |
| Doi | 10.1093/aje/kwp067 |
| Pmid | 19395695 |
| Wosid | WOS:000266109400008 |
| Url | http://dx.doi.org/10.1093/aje/kwp067 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution, indoor; attention deficit disorder with hyperactivity; child development; cognition; fossil fuels; glutathione transferase; nitrogen dioxide; polymorphism, genetic |
| Is Qa | No |