Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat
Nikonorow, M; Mazur, H; Piekacz, H
HERO ID
61571
Reference Type
Journal Article
Year
1973
Language
English
PMID
| HERO ID | 61571 |
|---|---|
| In Press | No |
| Year | 1973 |
| Title | Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat |
| Authors | Nikonorow, M; Mazur, H; Piekacz, H |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 26 |
| Issue | 2 |
| Page Numbers | 253-259 |
| Abstract | Toxicologic effects of di-(2-ethylhexyl) phthalate, di-n-butyl phthalate, di-(n-octyl)tin S,S′-bis-(isooctyl mercaptoacetate), dibenzyltin S,S′-bis-(isooctyl mercaptoacetate), as well as their effect on reproduction and fetal development were examined in Wistar rats. In a 3-month toxicity study all the compounds produced a statistically significant increase in the mean liver weight of the animals. Rats fed dietary levels 0.35% of di-(2-ethylhexyl)phthalate and 0.02% of di-(n-octyl)tin S,S′-bis-(isooctyl mercaptoacetate) for periods up to 12 months showed a significant decrease in body weight and an increase in kidney weight; furthermore, di-(2-ethylhexyl) phthalate caused liver enlargement. Red and white blood cell counts, hemoglobin concentration and histopathology of liver, kidneys, and spleen were within normal limits. Reproduction studies showed an increased number of resorptions and decreased fetal body weights. Doses of 0.02 and 0.04 g/kg of di-(n-octyl)tin S,S′-bis-(isooctyl mercaptoacetate) also caused a 17% incidence in fetal deaths. No gross abnormalities were found in the fetuses. |
| Doi | 10.1016/0041-008X(73)90259-7 |
| Pmid | 4751104 |
| Wosid | WOS:A1973R037600010 |
| Url | http://dx.doi.org/10.1016/0041-008X(73)90259-7 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Toxicol. Appl. Pharmacol. 26: 253-259. |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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