Methanol toxicity in a newborn
Belson, M; Morgan, BW
HERO ID
59081
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 59081 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Methanol toxicity in a newborn |
| Authors | Belson, M; Morgan, BW |
| Journal | Clinical Toxicology |
| Volume | 42 |
| Issue | 5 |
| Page Numbers | 673-677 |
| Abstract | BACKGROUND: Methanol poisoning during human pregnancy rarely has been described. We report the first human newborn with a documented methanol concentration resulting from maternal exposure. CASE REPORT: A 28-year-old pregnant woman EGA 30 weeks with HIV infection and asthma presented to the emergency department in respiratory distress. She was acidotic (pH 7.17) with an anion gap of 26, and fetal bradycardia was noted. Her son was delivered by emergent C-section (birthweight 950 g, Apgars 1 and 3) and required aggressive resuscitation. During his hospital course, acidosis (initial pH 6.9) persisted despite fluid, blood, and bicarbonate administration. His mother also had persistent metabolic acidosis despite fluids, bicarbonate, and dopamine. Results of other laboratory tests on the mother included undetectable ethanol and salicylates and an osmolar gap of 41. An ethanol drip was initiated for the mother 36 h after admission when a methanol level of 54 mg/dL was reported. When consulted on hospital day 3, our regional poison center recommended hemodialysis for the mother and administering fomepizole and testing the methanol level of the newborn (61.6 mg/dL). Because the infant developed a grade 4 intraventricular bleed, no further therapy was offered, and he died on day 4. His mother died on day 10. CONCLUSION: Fatal neonatal methanol toxicity can result from transplacental exposure. |
| Pmid | 15462163 |
| Wosid | WOS:000224104600015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.J. Toxicol. Clin. Toxicol. 42: 673-677. |
| Is Public | Yes |
| Language Text | English |
| Keyword | methanol; acidosis; neonate; newborn; pregnancy |
| Is Qa | No |