Analysis of hexafluoropropylene oxide-dimer acid (HFPO-DA) by Liquid Chromatography-Mass Spectrometry (LC-MS): Review of Current Approaches and Environmental Levels
Mullin, L; Katz, D; Riddell, N; Plumb, R; Burgess, JA; Yeung, LWY; Jogsten, IE
HERO ID
5883629
Reference Type
Journal Article
Year
2019
Language
English
PMID
| HERO ID | 5883629 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Analysis of hexafluoropropylene oxide-dimer acid (HFPO-DA) by Liquid Chromatography-Mass Spectrometry (LC-MS): Review of Current Approaches and Environmental Levels |
| Authors | Mullin, L; Katz, D; Riddell, N; Plumb, R; Burgess, JA; Yeung, LWY; Jogsten, IE |
| Journal | Trends in Analytical Chemistry |
| Volume | 118 |
| Page Numbers | 828-839 |
| Abstract | Emerging per- and polyfluorinated compounds (PFAS) compounds are of increasing interest for environmental monitoring, one being hexafluoropropylene oxide-dimer acid (HFPO-DA), commonly referred to as GenX. The following review describes existing liquid chromatography-mass spectrometry (LC-MS) methods used to analyze HFPO-DA, including sample preparation and method sensitivity relative to other PFAS. Analytical challenges are also described, in particular the significant formation of in-source fragmentation, dimer and dimer adducts which detract from [M-H]- signal. Lastly, detected levels of HFPO-DA in environmental and biological samples are compared across the limited number of available field exposure studies, which found several μg/L concentrations in water samples taken near fluorochemical plant discharges. |
| Doi | 10.1016/j.trac.2019.05.015 |
| Pmid | 31501636 |
| Wosid | WOS:000486383900064 |
| Url | http://www.sciencedirect.com/science/article/pii/S0165993619302341 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | HFPO-DA; GenX; Negative polarity electrospray ionisation; Liquid chromatography; Mass spectrometry |