Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene
Carlson, GP
HERO ID
58144
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 58144 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene |
| Authors | Carlson, GP |
| Journal | Toxicology Letters |
| Volume | 19 |
| Issue | 1-2 |
| Page Numbers | 113-117 |
| Abstract | Control rabbits or those treated with 2,4-dichloro-6-phenylphenoxyethyldiethylamine-HBr (Lilly 18947), an inhibitor of microsomal mixed-function oxidases, were exposed to 5200 ppm tetrachloroethylene in an inhalation chamber under dynamic airflow conditions for 1 h. Even at this high concentratio, tetrachloroethylene was only weakly arrhythmogenic when animals were challenged with up to 3 μg/kg epinephrine i.v. Unlike trichloroethylene and methylchloroform, the arrhythmogenicity of tetrachloroethylene was not potentiated by treatment with Lilly 18947. |
| Doi | 10.1016/0378-4274(83)90270-9 |
| Pmid | 6658816 |
| Wosid | WOS:A1983RS79300017 |
| Url | http://www.sciencedirect.com/science/article/pii/0378427483902709 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Toxicol. Lett. 19: 113-117. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Perchloroethylene; inhibition by Lilly 18947; potentiation; heart; inhalation |
| Is Qa | No |