Supercritical-fluid extraction of bilobalide and ginkgolides from Ginkgo biloba leaves by use of a mixture of carbon dioxide, methanol, and water
Choi, YH; Kim, J; Yoo, KP
HERO ID
5778961
Reference Type
Journal Article
Year
2002
Language
English
| HERO ID | 5778961 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Supercritical-fluid extraction of bilobalide and ginkgolides from Ginkgo biloba leaves by use of a mixture of carbon dioxide, methanol, and water |
| Authors | Choi, YH; Kim, J; Yoo, KP |
| Journal | Chromatographia |
| Volume | 56 |
| Issue | 11-12 |
| Page Numbers | 753-757 |
| Abstract | Supercritical-fluid extraction (SFE) with pure carbon dioxide and with carbon dioxide modified by addition of methanol, ethanol, or water have been used to extract bilobalide and ginkgolides A, B, and C from Ginkgo biloba leaves. Each extract was analyzed by HPLC-ESIMS. Although addition of methanol or ethanol led to enhonced SFE yields of the compounds compared with use of pure carbon dioxide, the amounts extracted were only 10% those obtained by extraction with an organic solvent such as methanol or acetone-water 1:1. Addition of small amounts (4%, v/v) of water as modifier of the carbon dioxide, however, led to a dramatic improvement in the extraction yield of the compounds - to amounts which were 80-150% of the yields obtained by extraction with organic solvent. In addition, levels of ginkgolic acids, the toxic constituents of Ginkgo biloba leaves, extracted by SFE with carbon dioxide-methanol-water, 80:16:4, were substantially lower after continuous pre-extraction with n-hexane and with pure carbon dioxide. |
| Doi | 10.1007/BF02492479 |
| Wosid | WOS:000179861600015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036907199&doi=10.1007%2fBF02492479&partnerID=40&md5=0c222c56681bb91f5956fe6ebff4eab6 |
| Is Public | Yes |
| Language Text | English |
| Keyword | supercritical-fluid extraction; selective extraction; Ginkgo biloba; ginkgolides A, B, C; ginkgolic acid |