Blood methanol concentrations in one-year-old infants administered graded doses of aspartame
Stegink, LD; Brummel, MC; Filer, LJ, Jr; Baker, GL
HERO ID
56316
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 56316 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Blood methanol concentrations in one-year-old infants administered graded doses of aspartame |
| Authors | Stegink, LD; Brummel, MC; Filer, LJ, Jr; Baker, GL |
| Journal | Journal of Nutrition |
| Volume | 113 |
| Issue | 8 |
| Page Numbers | 1600-1606 |
| Abstract | ABSTRACT Blood methanol concentrations were measured in 24 1-year-old infants administered aspartame, a dipeptide methyl ester sweetener. The doses studied included a dose projected to be the 99th percentile of daily ingestion for adults (34 mg/kg bodyweight), a very high use dose (50 mg/kg body weight) and a dose considered to be in the abuse range (100 mg/kg body weight). Blood methanol values in infants were compared to values observed previously in adults administered equivalent doses of aspartame. Methanol concentrations were below the level of detection (0.35 mg/dl) in the blood of 10 infants administered aspartame at 34 mg/kg body weight, but were significantly elevated (P ½= 0.05) after ingestion of aspartame at 50 and 100 mg/kg body weight. At the latter doses, mean peak blood methanol concentrations and the area under the blood methanol concentration-time curve increased in proportion to dose. Mean (?SEM) peak blood methanol concentration was 0.30 ? 0.10 mg/100 ml at a 50mg/kg body weight aspartame dose (n = 6) and 1.02 ? 0.28 mg/ml at the 100 mg/kg body weight dose (n = 8). Blood methanol values in infants were similar to those observed in normal adults. |
| Pmid | 6875695 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.J. Nutr. 113: 1600-1606. |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>ASPARTAME</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>METHYL ALCOHOL</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>AGE FACTORS</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>BLOOD</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>ADMINISTRATION AND DOSAGE</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>METABOLISM</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>TOXICITY</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>DIPEPTIDES</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>DOSE-RESPONSE RELATIONSHIP</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>HUMAN</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>INFANT</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>TIME FACTORS</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>SWEETENING AGENTS</kw> |
| Is Qa | No |
| Relationship(s) |
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