Oncogenic response of strain A/J mice to inhaled chemicals
Adkins, B; Van, SEW; Simmons, JE; Eustis, SL
HERO ID
5597956
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 5597956 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Oncogenic response of strain A/J mice to inhaled chemicals |
| Authors | Adkins, B; Van, SEW; Simmons, JE; Eustis, SL |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 17 |
| Issue | 2 |
| Page Numbers | 311-322 |
| Abstract | Strain a/j mice were exposed by inhalation for 6 hours/day, 5 days/week, for six months to carbon disulfide, 1,2-dibromoethane, ethylene oxide, naphthalene, nitrogen dioxide, or vinyl chloride. Significant increases in pulmonary adenoma formation were observed following exposure to 300 ppm carbon disulfide; 20 and 50 ppm 1,2-dibromoethane; 70 and 200 ppm ethylene oxide; 10 ppm no 2; and 50, 200, and 500 ppm vinyl chloride compared with control animals. Exposure of mice to 30 ppm naphthalene did not elicit a significant adenoma response. The results provide further information for the validation of this in vivo model as a tool for predicting oncogenic potential following chemical exposure. |
| Doi | 10.1080/15287398609530825 |
| Pmid | 3083111 |
| Wosid | WOS:A1986A683700014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022651351&doi=10.1080%2f15287398609530825&partnerID=40&md5=4711fba8ccdac0c5c84e03869aecace1 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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